Your pancreas normally produces enzymes every time you eat, so CREON needs to replace those enzymes every time you eat. The CREON capsules are taken with meals and snacks so they can enter the stomach at the same time as food. CREON spheres dissolve in the starting point of the small intestine, called the duodenum. You are leaving the AbbVie Website and connecting to a site that is neither owned nor under the control of AbbVie.
AbbVie is not responsible for the contents of any such site or any further links from such site. Your dietitian , doctor or nurse can tell you how to work out the best dose of enzymes for you.
They should review the dose regularly. There is no set dose of enzymes for each day. You will need to take more for larger meals and more for fatty foods, as these need more enzymes to digest them. Speak to your doctor or dietitian before making any major changes to your diet. You may find it helpful to keep a diary of what you have eaten, the dose of enzymes you took, and if this made your symptoms better.
This can help you work out if you are taking enough enzymes. Pancreatic enzymes only work when they are taken with food. These include:. The only foods that really give me problems are fatty, greasy ones and sometimes dairy. Since taking Creon I have noticed a big improvement.
It is best to take the capsules whole as they work better this way. If you find it difficult to swallow the capsules, speak to your doctor, nurse or dietitian. There are smaller capsules available, but you may have to take more of these to make up the dose. You can open the capsule and mix the granules inside with a teaspoon of cold, soft, acidic food — such as a smooth apple sauce, fruit puree, apricot jam or fruit yoghurt.
Swallow the food straight away and wash it down with a cool drink to rinse your mouth. How do I take pancreatic enzyme replacement therapy? For the best results, you should take Creon at the start of every meal and snack. If you skip a meal or snack, skip that Creon dose, too. If you forget to take Creon with a meal or snack, just skip that dose of Creon. Wait and take your usual dose with your next meal or snack. Plan ahead by keeping Creon with you at all times. Store it in your desk at work or school.
Or tuck it in your bag or purse. Just make sure to keep Creon capsules cool and dry. Creon is meant to be used as a long-term treatment. But this depends on your overall health and other factors. Creon can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Creon.
These lists do not include all possible side effects. For more information about the possible side effects of Creon, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.
Most of these side effects may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. One clinical trial looked at the safety of using Creon in children ages 7 to 11 years.
In this study, side effects were seen in:. None of the children quit the study due to side effects. And none of the side effects reported in the children were serious. Their ages ranged from 4 months to 6 years. In this study, during Creon treatment:. You may wonder how often certain side effects occur with this drug. Below is some detail on certain side effects this drug may cause.
The side effects described below were seen in clinical studies involving both adults and children taking Creon. As with most drugs, some people can have an allergic reaction after taking Creon.
Call your doctor right away if you have an allergic reaction to Creon, as the reaction could become severe. But some symptoms of mild allergic reaction, such as rash and itching, have been reported since Creon was released onto the market. For example, pancrelipase, which Creon contains, comes from the pancreas of pigs.
So if you have an allergy to pork, you may be allergic to pancrelipase medications, including Creon. Severe allergies with other products made with pig pancrelipase have occurred.
But possible symptoms of severe allergies, such as certain skin problems, have been reported since Creon was released onto the market. Tell your doctor if you have a pork allergy before starting Creon.
They can help you weigh the risks and benefits of using this medication. Pancrelipase medications, such as Creon, are made using the pancreas of pigs. They can check to see if you have an infection. Creon could increase your risk for fibrosing colonopathy. With fibrosing colonopathy, your colon becomes narrowed inside because of scarring or strictures. But it has been reported with other pancreatic enzyme replacement products similar to Creon.
Fibrosing colonopathy is a serious condition. Call your doctor right away if you have any of its symptoms. These can include any new or worsening:. You may be able to lower your risk for fibrosing colonopathy by sticking to your Creon treatment plan as prescribed by your doctor. If you develop the condition, you may need surgery to treat it. Or your doctor may lower your Creon dosage to try and keep the condition from getting worse. Call your doctor right away if you have any of the symptoms listed above.
Digestive side effects have been seen with Creon. In these studies, vomiting occurred in:. In this study, the following digestive system problems were reported:. Diarrhea, nausea, and constipation have also been seen in people taking Creon. Instead, people reported having diarrhea, nausea, and constipation after Creon was released onto the market.
Then share this information with your doctor. Digestive problems could be a side effect of Creon. Digestive symptoms could also be caused by your diet or a health condition you may have. Keep in mind that certain digestive symptoms may indicate a more serious side effect of Creon called fibrosing colonopathy. These symptoms include gas, abdominal belly pain, and constipation. Instead, tell your doctor right away. Some people using Creon have had various skin conditions. Instead, people reported having skin conditions after Creon was released onto the market.
Call your doctor right away if you have a severe rash, itching, or hives while using Creon. In some cases, these symptoms could indicate a serious allergic reaction to the drug.
Blurred vision has been reported in some people using Creon. Instead, people reported having blurred vision after Creon was released onto the market. Keep in mind that blurry vision could also be a symptom of either high or low blood sugar levels. And either can happen in people with certain conditions that Creon is used to manage.
In addition, having abnormal blood sugar levels is a possible side effect of Creon. Instead, tell your doctor about any vision problems you have with Creon treatment. You doctor can check to see if you have any conditions that could affect your blood sugar level or cause blurry vision. Some people have had myalgia muscle pain and muscle spasms while taking Creon. Instead, some people reported having myalgia and muscle spasms after Creon was released onto the market.
And Creon is used in people with chronic pancreatitis. If you have new or worsening pain, especially abdominal belly or back pain, talk with your doctor. Some may be a better fit for you than others. They can tell you about other medications that may work well for you. Note : Some of the drugs listed below are used off-label to treat EPI caused by certain conditions.
As with all medications, the cost of Creon can vary. To find current prices for Creon in your area, check out GoodRx. The cost you find on GoodRx.
Keep in mind that you may be able to get a day supply of Creon. If approved by your insurance company, getting a day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost.
Before approving coverage for Creon, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered. If you need financial support to pay for Creon, or if you need help understanding your insurance coverage, help is available.
AbbVie, the manufacturer of Creon, offers two support programs that you may qualify for depending on your specific condition.
It also offers the myAbbVie Assist program, which provides free medication to people who qualify. Creon may be available through a mail-order pharmacy. Some Medicare plans may help cover the cost of mail-order medications. Generics tend to cost less than brand-name drugs. Creon may also be used off-label for other conditions.
These specific conditions are described below. Pancreatic enzymes are substances that your pancreas makes to help break down fats, proteins, and carbohydrates from your diet.
Creon helps people with EPI by replacing the natural digestive enzymes in their small intestine. For this use, Creon can be given to infants, children, and adults of all ages. Cystic fibrosis CF is a genetic condition. CF causes thick, sticky mucus in certain body parts, including the pancreas. With CF, the thick, sticky mucus clogs the duct passageway between your pancreas and small intestine. This blocks pancreatic enzymes from reaching your small intestine to help digest food. With CF, you can have maldigestion poor digestion and malabsorption poor absorption , leading to issues including:.
In addition, Creon has been found effective in clinical trials for this purpose. One study included people who were ages 12 to 43 years. Some people took Creon 4, lipase units per gram of total fat intake daily for 5 to 6 days. Then they switched to a placebo no active treatment for 5 to 6 additional days. Other people took the placebo for 5 to 6 days. Then they switched to Creon at the same dosing as the other group for 5 to 6 additional days.
During the study, both groups of people ate a high-fat diet. Researchers reported the following results, which were taken from both groups of people in the study:.
Each of the conditions listed above cause EPI because they can affect the health of your pancreas. Chronic pancreatitis is an ongoing condition.
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