When exceeding approved doses, diphenhydramine produces powerful deliriant effects. Diphenhydramine was first synthesized in In , it became the first prescription antihistamine approved by the U.
Food and Drug Administration. It was approved for over-the-counter use in the s. According to user reports, diphenhydramine has a non-linear dose-response, meaning the effects do not correspond directly with the dose. Lower doses produce a body high effect, while higher doses produce a state of delirium in which the user sees and hears fully-formed, extremely convincing hallucinations.
Doses between these two extremes are uncomfortable and dysphoric. Diphenhydramine is frequently reported to produce significant nausea and bodily discomfort "body load". Most users who try diphenhydramine typically do not report positive effects and do not wish to repeat the experience.
The toxicity of recreational diphenhydramine use has not been studied. Anecdotal reports suggest that heavy use may cause persisting hallucinations and cognitive and memory impairments. It is highly advised to use harm reduction practices if using this substance.
Diphenhydramine was discovered in by George Rieveschl, a former professor at the University of Cincinnati. In the s diphenhydramine was found to inhibit reuptake of the neurotransmitter serotonin.
Diphenhydramine, or 2- diphenylmethoxy -N,N-dimethylethanamine, is an organic compound belonging to the ethanolamine class. The chemical structure of diphenhydramine consists of an ethylamine chain with two methyl groups bonded to the terminal nitrogen group R N. Additionally, this ethylamine chain is substituted at R 2 with a diphenylmethoxy group, forming an ether. The diphenylmethoxy group consists of two aromatic phenyl rings bonded the carbon member of a methoxy group CH 3 O-.
Diphenhydramine is an inverse agonist of the peripheral histamine H 1 receptor and a central histamine H 1 receptor. Diphenhydramine is an acetylcholine receptor antagonist. Although the precise mechanism is not understood, the inhibition of the action of acetylcholine is thought to be primarily responsible for the delirium, sedation and intensely realistic hallucinations alongside the extremely uncomfortable and dysphoric physical side effects.
Diphenhydramine has been shown to block sodium channels and inhibit the reuptake of serotonin. The receptor binding affinities are listed as follows: [11] [12]. According to user reports, diphenhydramine displays a non-linear dose-response, meaning the effects don't correspond directly with the dose.
Doses under mg are reported to produce restlessness, muscle relaxation , and a body high while doses above mg begin to produce a state of delirium in which the user sees and hears fully-formed, extremely convincing hallucinations.
Doses in between these two extremes are said to be uncomfortable and dysphoric. Nausea and bodily discomfort "body load" is reported almost universally. Disclaimer: The effects listed below cite the Subjective Effect Index SEI , an open research literature based on assorted anecdotal reports and the personal analyses of PsychonautWiki contributors.
As a result, they should be taken with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.
Anecdotal reports which describe the effects of this compound within our experience index include:. Dimenhydrinate DMH is a combination drug of Diphenhydramine and 8-Chlorotheophylline [17] , marketed as Draminate , Dramamine , and Gravol among others, it is used to treat nausea. It is most commonly available as tablets, although it is also available in liquid form and as a suppository.
This stimulant effect is also reported to make the trip more restless and dysphoric, with the added negative of being too wakeful to sleep the trip away.
This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Call your doctor if the condition you are treating with diphenhydramine does not improve, or if you have a fever with a headache, cough, or skin rash. Do not use diphenhydramine for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms. This medicine can affect the results of allergy skin tests. Tell any doctor who treats you that you are using diphenhydramine.
Since diphenhydramine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.
Overdose symptoms may include vomiting, confusion, severe drowsiness, ringing in your ears, no urination, very dry eyes and mouth, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure. Benadryl is absorbed quickly in the body. You should only take Benadryl for a short amount of time, unless your doctor tells you to take it for longer.
If you use Benadryl for two weeks or longer, your body can start to become dependent on it. A typical dosage for adults and children ages 12 and older is one to two tablets every four to six hours. For example, some research has shown the medicine may help obsessive compulsive disorder OCD and general anxiety. Health Topics. Health Tools. Benadryl Diphenhydramine.
Generic Name: Diphenhydramine. Reviewed: November 17, It may help relieve: Watery, itchy, red, or irritated eyes Runny nose Sneezing Hives Itching The medicine is also taken to help treat or prevent insomnia or motion sickness. You should not use diphenhydramine if you are allergic to it. Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: an enlarged prostate or urination problems; asthma, chronic obstructive pulmonary disease COPD , or other breathing disorder; glaucoma; or a thyroid disorder.
Side Effects. Side Effects What are the side effects of Benadryl Diphenhydramine? Recent data shows that the following age groups have abused inhalants at least once in the past year: Tl;dr: Do some other psychedelic. The effects vary for everyone. Common side effects of Benadryl include: drowsiness, fatigue,. Benadryl is a brand name over-the-counter antihistamine medication.
Many thanks to our study, you are ensured the very best combination of high quality and cost. No body high or euphoria. It starts to get hard on your heart at higher doses.
You might wander off and get lost. It made me feel like my body was heavy, as if gravity had increased. Doxylamine succinate Unisom SleepTabs. This is a very common spice. I know it's not safe and the drug is sold as a sleep aid and not meant for this, but I kinda want to give it a try if it will get me high. Make sure your phone is turned off or put away somewhere where no one cant see you're on wikihow trying to get high. Benadryl is an antihistamine utilized for the symptoms of allergic responses.
Benadryl diphenhydramine is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of Parkinsonism. I waited an hour before I felt any effects.
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